Not so common but one certainly that we all learn about in medical school called Kallmann syndrome which is we call a central defect syndrome. It is when a person has a defect of the midline of essential your body, and in the pituitary gland, they’re not secreting those hormones, especially FSH. They’re not there, and they don’t have the actual material that the tissue to secrete it. So the testicle never gets the stimulus to make testosterone or to make sperm. And in fact, those men are usually diagnosed late in adolescence when they fail to go through puberty.